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The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases

Author

Summary, in English

Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results.

Publishing year

2017

Language

English

Publication/Series

PeerJ

Volume

2017

Issue

9

Links

Document type

Journal article

Publisher

PeerJ

Topic

  • Cell and Molecular Biology
  • Other Clinical Medicine

Keywords

  • Bacterial effectors
  • Mitochondrial carriers
  • Proteases
  • Structure prediction

Status

Published

Research group

  • Clinical Protein Science and Imaging

ISBN/ISSN/Other

  • ISSN: 2167-8359