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Acute coronary artery occlusion should be treated with urgent revascularization. ECG is important in the triage of patients with acute coronary syndrome. ST deviation depends on the relation between the location of the transmural ischemia and the positive poles of the 12 ECG leads. In acute occlusion of the left circumflex artery, ST elevation in two contiguous leads is not always present. Instead, isolated ST depression in leads V1–V3 may be present and represents a »STEMI-equivalent« pattern. Detection of acute occlusion of the left circumflex artery may be improved either by including inverted leads or by recording from electrodes on the posterior thorax.