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CNS Gene Therapy

Faculty of Medicine / Department of Experimental Medical Science

Fax number: +46 46 222 05 31

Visiting address: Sölvegatan 19, BMC A11, 221 84 Lund

Description

In the gene therapy group our main interest is to develop systems for sufficient and sustained expression of transgenes in the CNS. We are using gene transfer to express trophic factors or neurotransmitter-producing enzymes in animal models of neurodegenerative disease. We are currently working with three different vector systems: adeno-associated viral, retroviral and lentiviral. These vectors can be used both for direct injection (in vivo gene transfer) or transduction of cells in culture for subsequent transplantation (ex vivo gene transfer). To address the problem of sustained expression in vivo (a major limitation of many gene transfer methods as of now) we are investigating the use of different promoters, post-transcriptional regulating elements and vectors.

Staff

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  • Elin Arvidsson

    Doctoral student

    elin [dot] arvidsson [at] med [dot] lu [dot] se

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